Loyola cut No.3 Kentucky's lead to four points on the first possession of the second half, but the Wildcats later used a 15-2 run to put Thursday's men's basketball game out of reach in an 87-63 win before an announced 22,274 at Rupp Arena.
"We withstood the first couple of minutes when they came out strong, and then we made it a really close game in the first half," Loyola coach Jimmy Patsos said.
Erik Etherly, who led Loyola (8-3) with 14 points and 11 rebounds, caught a lob pass from Shane Walker and laid it in 13 seconds into the second half to cut the Wildcats' lead to 45-41.
But Darius Miller made back-to-back baskets in the paint on Kentucky's next two possessions, and the Wildcats (11-1) were up by eight.
Loyola's Justin Drummond hit a 3-pointer with less than three seconds on the shot clock to cut Kentucky's lead to 49-44 with 18:23 left.
After Michael Kidd-Gilchrest made a pair of free throws for the Wildcats, Drummond caught a long outlet pass from Etherly and made a layup to make it a five-point game.
Kentucky scored the next five points, however, and that was as close as Loyola would come for the remainder of the game.
Etherly scored at 16:11 to pull Loyola within eight at 56-48, but a dunk by Kidd-Gilchrest on the ensuing possession started a 15-2 Kentucky run that put the Wildcats up 71-50 on a jumper by Kyle Wiltjer at 11:02.
Wiltjer came off the bench and led all scorers with 24 points. He was 7-for-11 from the field with three 3-pointers and 7-for-8 from the free-throw line.
Kidd-Gilchrest and Anthony Davis each scored 15 points, and Miller added 13. Davis matched Etherly for game-high honors with 11 rebounds.
No. 17 Indiana 89, UMBC 47: Christian Watford scored 22 points, Jordan Hulls had 16 and the host Hoosiers (12-0) continued their best start in 36 years.
Matt Roth added 14 points for Indiana, Cody Zeller had 13 and Watford led all players with 10 rebounds.
The Hoosiers, who shot almost 41percent from 3-point range, are off to their best start since the 1975-76 team went 32-0 on the way to winning the national title.
Chase Plummer, Ryan Cook and Quentin Jones had 10 points apiece to lead UMBC (1-10).
The Retrievers have lost three games in a row since their only win of the season, which came Dec. 10 against Towson.
Savannah State 45, Mount St. Mary's 41: Josh Castellanos hit the only 3-pointer for the Mount to cut the lead to 44-41 with 1:50 left to play, but in the final minutes, Mount St. Mary's (1-10) turned the ball over and missed a 3-pointer to fall to the host Tigers (5-8).
Danny Thompson led the Mountaineers with eight points and Castellanos added seven. Rashad Hassan led all scorers with 14 points and Preston Blackmon had nine for Savannah State.
The Mountaineers shot 42.9 percent from the field but committed 24 turnovers, leading to 18 Savannah State points.
Presbyterian 58, Navy 42: Al'Lonzo Coleman scored 22 points, making all nine of his shots, to lead the host Blue Hose (6-5) past the Midshipmen (3-9), who have lost five straight.
Coleman scored two baskets in the game's first minute, and the Blue Hose opened a 17-6 lead with 14:06 left in the first half. They never trailed after that, leading 32-20 at halftime.
J.J. Avila led Navy with 21 points, but no other player scored more than five points for the Mids.
Towson 70, Delaware State 59: The visiting Tigers (9-2) rallied from a 10-point second-half deficit to win their fifth straight. Krystal Parnell scored 22 points to lead three Tigers in double figures.
The Hornets (3-10) led 43-33 before Tanisha McTiller hit a jumper at 11:29 to start a 7-0 run to cut the lead to 43-40. Towson used a 10-1 run to take a 50-48 lead with seven minutes left.