Kathrin Zettel of Austria won Sunday's women's World Cup slalom in Maribor, Slovenia, for her second victory in as many days.
Maria Riesch of Germany took the overall lead from Lindsey Vonn by finishing third.
Vonn struggled throughout the first leg, losing the ideal line several times and never threatening to equal the pace of the leaders. She finished 4.55 seconds back in 46th place.
The American star, who won three straight races last weekend, has now failed to score points in three straight races. She trails Riesch by 28 points with 13 races left in the season.
"It's nice to be the leader, but there are a lot of speed races left and Lindsey will be hard to beat again," Riesch said.
In the men's World Cup slalom race in Wengren, Switzerland, Ivica Kostelic of Croatia won his first title this season and 10th overall.
Americans Ted Ligety and Jimmy Cochran finished eighth and 12th. Bode Miller skied out in the top half and was among 22 of 69 racers who did not finish the first run, including two-time world champion Mario Matt of Austria and Manfred Moelgg of Italy, the 2008 World Cup slalom champion.
Benjamin Raich of Austria finished fourth and closed within 18 points of overall points leader Carlo Janka of Switzerland.