Bryant, who finished with the highest-scoring game in the NBA this season, left to a loud ovation after the 24th 50-point game of his career. He went 19-for-31 from the field and hit all 20 free throws.
Pau Gasol added 31 points and 14 rebounds in the Lakers' first game since losing Bynum, their starting center, for eight to 12 weeks with a torn medial collateral ligament in his right knee.
Bynum was hurt Saturday at Memphis. The center isn't expected to need surgery and said he was confident he would return in time for the playoffs.
Trail Blazers 97, Hornets 89: : Visiting Portland (30-17) overcame a 17-point deficit after Chris Paul was injured to beat New Orleans (28-17) for its fifth straight victory.
Paul (12 points, 13 assists) left the game late in the third quarter with a strained right groin with the Hornets ahead 72-55.
Portland then outscored New Orleans 26-7 during the next seven minutes.
Mavericks 105, Magic 95: : Dirk Nowitzki had 29 points and six rebounds, and visiting Dallas (28-19) held Orlando (36-11) to 3-for-20 shooting from three-point range for its third straight win.
Dwight Howard had 35 points and 11 rebounds, but the Magic lost All-Star point guard Jameer Nelson in the third quarter with a dislocated right shoulder.
Heat 119, Clippers 95: : Dwyane Wade had 32 points and nine assists, Michael Beasley added 18 points, and host Miami (26-21) broke a two-game losing streak by beating Los Angeles (10-38).
Suns 129, Kings 81: : Jason Richardson scored 16 of his 24 points in the first quarter, Amare Stoudemire had 25 points, and Phoenix (26-21) ended a three-game home skid with its most lopsided win of the season, over Sacramento (11-39).
Jazz 105, Bobcats 86: : Ronnie Brewer scored 14 of his 21 points in the second half, and Utah (27-22) rallied from a sluggish start to beat visiting Charlotte (19-29).
