Studies show cancer drugs injure brain

Findings back claims of patients on chemo

December 01, 2006|By Thomas H. Maugh II | Thomas H. Maugh II,LOS ANGELES TIMES

Cancer chemotherapy can severely damage the brain, killing crucial brain cells and causing key parts of the brain to shrink, according to two studies released this week.

The new findings add to a growing body of evidence suggesting that the phenomenon of "chemobrain" -mental fuzziness, memory loss and cognitive impairment often reported by cancer patients but often dismissed by oncologists - is a serious problem.

"Those of us on the front lines have known this for a long time, but now we have some neuropathological evidence that what we are seeing involves an anatomic change," said Dr. Stewart Fleishman, director of cancer supportive services at Beth Israel Medical Center and St. Luke's-Roosevelt Hospital Center in New York.

He said the most common question he hears from patients when he gives a public lecture is: "My doctor doesn't believe me. How can I convince him this is real?"

The new studies should help convince physicians who are skeptical about the phenomenon, said Fleishman, who was not involved in the research.

Because chemotherapy is such a crucial component of cancer treatment and cannot be abandoned, scientists are calling for more research on shielding the brain from its toxic effects.

"There are no easy answers," said Dr. Patricia K. Duffner of the State University of New York at Buffalo School of Medicine. "We must balance the need for survival with quality of life."

Several studies have suggested that from 40 percent to 80 percent of cancer patients receiving chemotherapy suffer from chemobrain. The problem is particularly severe for breast cancer patients, Fleishman noted, because the treatment induces hormonal changes that can also produce memory problems.

It has also become more common as chemotherapy has increasingly been used at an early stage of treatment rather than as a treatment of last resort.

Dr. Masatoshi Inagaki of the National Cancer Center Hospital in Shikoku, Japan, led a team that used high-resolution magnetic resonance imaging to compare the brains of 51 women who received chemotherapy for breast cancer with those of 54 patients who had only surgery.

Inagaki and his colleagues reported in the current issue of the journal Cancer that, one year after treatment, key areas of the brain involved in cognitive processes were significantly smaller in the women who had chemotherapy.

In the second study, biomedical geneticist Mark D. Noble and colleagues at the University of Rochester Medical Center exposed human brain cells and brain tumor cells grown in a laboratory dish to three of the most commonly used cancer drugs, carmustine, cisplatin and cytarabine.

They reported yesterday in the Journal of Biology that low doses of the drugs caused a 60 percent to 90 percent reduction in the viability of the brain cells but had little effect on tumor cells. Killing 40 percent to 80 percent of the tumor cells required doses that killed up to 100 percent of the brain cells.

Thomas H. Maugh II writes for the Los Angeles Times.

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